Research & Development

CELAGENEX has developed cutting edge technology platform that combines clinically proven unique biological metabolites (compounds) & bioavailability enhancers to regulate cellular metabolism.

The company has protected the discovery and application of its portfolio through extensive IP that includes thirteen issued and or filed and allowed to date with corresponding patents pending globally.

The company is conducting multiple studies that is validating its discovery and demonstrating value of its intellectual property.

Mitochondria are the ‘powerhouses’ of the cell due to their inherent ability to harvest energy in the form of ATP & simultaneously regulate cellular metabolism. Cellular and or Mitochondrial dysfunction drives the pathogenesis of wide variety of medical disorders like

Neurodegenerative Diseases (Post Stroke Syndrome, Diabetic Polyneuropathy, Neuralgias, Alzheimer’s Diseases, Multiple Sclerosis).
Liver Diseases (NASH, ASH),
Chronic Kidney Diseases (CKD)
Metabolic Syndrome, Type -2 Diabetes, PCOS, Unexplained infertility, Cardiac Ischemia & Musculoskeletal disorders.

Recent studies have indicated that targeting cellular metabolism & mitochondria to enhance their function may hold promise for attenuating these conditions. Cellular metabolism & Mitochondria directed therapies may have the ability to address multiple molecular abnormalities simultaneously and may prove to be more efficacious than compounds that target an isolated protein.

CELAGENEX strategy is directed towards achieving ‘Cellular & Mitochondrial Homeostasis’ by

Increasing cellular NAD+

AMPK Activation

mTORC pathway regulation

Enhancing Sirtuins activators

Harmonization and optimization of cellular electron transport system.

Different Areas of Research

Focus on NEUROREGENERATION

CELAGENEX is targeting different pathways to enhance endogenous production of Brain Derived Growth Factor (BDNF) especially in pre-frontal cortex. Increased BDNF is helping patients with ischemic stroke, traumatic brain injury (TBI), spinal cord injury (SCI) develop new neuronal connections.

Focus on NEUROPLASTICITY

Our research is able to demonstrate attenuation of increased NRLP3, Ac-p53 & Bax. This is responsible for neuroplasticity & increased neuronal survival in ischemic and traumatic conditions of brain.

Focus on NEUROPROTECTION

Our strategy to block NMDA receptors has shown to significantly reduce i-NOS & n-NOS activity and its impact on infarct size, tissue damage, apoptosis & inflammation.

Focus on Activation of Specific Genes.

Activation of specific genes called Sirtuin genes are shown to exhibit anti-inflammatory , anti-apoptotic, anti-oxidant, DNA repair actions in cells and tissues under stress (Neuronal cells, Hepatocelluar cells, cardiac myocytes , skeletal muscle cells)

Focus on Endothelial Function & Neuro-inflammation

Endothelial dysfunction is involved in progression of various microvascular complications of metabolic disorders. One such condition affecting millions worldwide is diabetic peripheral neuropathy. Our research is able to demonstrate significant improvement in oxygen and nutrient supply to affected neurons and alleviate inflammation and pain associated with this condition.

Focus on achieving cellular energy homoeostasis

Our quest to achieve cellular energy homeostasis by regulating m-TORC pathway is yielding amazing results